7 papers
Nanoscale Protein Diffusion in Supercooled Cryoprotectant Solutions
Maddalena Bin, Anita Girelli, Mariia Filianina +15
Vitrification during cryopreservation requires a quantitative understanding of protein transport in deeply supercooled cryoprotectant solutions, yet direct measurements at molecula…
Coherent X-rays reveal anomalous molecular diffusion and cage effects in crowded protein solutions
Anita Girelli, Maddalena Bin, Mariia Filianina +38
Understanding protein motion within the cell is crucial for predicting reaction rates and macromolecular transport in the cytoplasm. A key question is how crowded environments affe…
X-ray photon correlation spectroscopy of hydrated lysozyme at elevated pressures
Milla à hlfeldt, Maddalena Bin, Anita Girelli +12
Pressure provides a powerful parameter to control the protein conformation state, which at sufficiently high values can lead to unfolding. Here, we investigate the effects of incre…
Depletion-Induced Interactions Modulate Nanoscale Protein Diffusion in Polymeric Crowder Solutions
Michelle Dargasz, Nimmi Das Anthuparambil, Sebastian Retzbach +26
Macromolecular crowding plays a crucial role in modulating protein dynamics in cellular and in vitro environments. Polymeric crowders such as dextran and Ficoll are known to induce…
A pipeline for Megahertz X-ray Photon Correlation Spectroscopy on soft matter samples at the MID instrument of European XFEL
Aliaksandr Leonau, Felix Brausse, James Wrigley +27
In this paper we present the experimental protocol and data processing framework for Megahertz X-ray Photon Correlation Spectroscopy (MHz-XPCS) experiments on soft matter samples,…
Softness and Hydrodynamic Interactions Regulate Lipoprotein Transport in Crowded Yolk Environments
Nimmi Das Anthuparambil, Michelle Dargasz, Sonja Timmermann +27
Low-density lipoproteins (LDLs) serve as nutrient reservoirs in egg yolk for embryonic development and as promising drug carriers. Both roles critically depend on their mobility in…