3 papers
stat.ME2022
Bayesian Simultaneous Factorization and Prediction Using Multi-Omic Data
Sarah Samorodnitsky, Chris H. Wendt, Eric F. Lock
Understanding of the pathophysiology of obstructive lung disease (OLD) is limited by available methods to examine the relationship between multi-omic molecular phenomena and clinic…
stat.AP2021
A Hierarchical Spike-and-Slab Model for Pan-Cancer Survival Using Pan-Omic Data
Sarah Samorodnitsky, Katherine A. Hoadley, Eric F. Lock
Pan-omics, pan-cancer analysis has advanced our understanding of the molecular heterogeneity of cancer, expanding what was known from single-cancer or single-omics studies. However…
q-bio.QM2019
A Pan-Cancer and Polygenic Bayesian Hierarchical Model for the Effect of Somatic Mutations on Survival
Sarah Samorodnitsky, Katherine A. Hoadley, Eric F. Lock
We built a novel Bayesian hierarchical survival model based on the somatic mutation profile of patients across 50 genes and 27 cancer types. The pan-cancer quality allows for the m…