activity
20192026
most citedThe chemical Langevin equation: a path integral view of Gillespie's derivation

10 citations · 35 across the 13 of their papers we have counts for

collaborators

17 papers

cs.LG2026

Solvable models of learning to pursue a moving target

John J. Vastola, Kanaka Rajan

Agents tasked with intercepting a moving target must learn how to reach it, ideally as efficiently as possible. As observers of animal pursuit behavior have noticed, different stra…

q-bio.NC2026

Implications of hierarchical Markov models of behavior: on irreversibility, predictability, and dimensionality

John J. Vastola, Kanaka Rajan

The maturation of quantitative tools for studying the high-level structure of animal behavior, and especially tools which represent spontaneous behavior as a sequence of stereotype…

cs.LG2025

A Variational Manifold Embedding Framework for Nonlinear Dimensionality Reduction

John J. Vastola, Samuel J. Gershman, Kanaka Rajan

Dimensionality reduction algorithms like principal component analysis (PCA) are workhorses of machine learning and neuroscience, but each has well-known limitations. Variants of PC…

cs.LG2025

Gradient Descent as Loss Landscape Navigation: a Normative Framework for Deriving Learning Rules

John J. Vastola, Samuel J. Gershman, Kanaka Rajan

Learning rules -- prescriptions for updating model parameters to improve performance -- are typically assumed rather than derived. Why do some learning rules work better than other…

cs.AI2025

Deep RL Needs Deep Behavior Analysis: Exploring Implicit Planning by Model-Free Agents in Open-Ended Environments

Riley Simmons-Edler, Ryan P. Badman, Felix Baastad Berg +5

Understanding the behavior of deep reinforcement learning (DRL) agents -particularly as task and agent sophistication increase- requires more than simple comparison of reward curve…

cs.LG2025

Generalization through variance: how noise shapes inductive biases in diffusion models

John J. Vastola

How diffusion models generalize beyond their training set is not known, and is somewhat mysterious given two facts: the optimum of the denoising score matching (DSM) objective usua…

q-bio.NC2025

Optimal packing of attractor states in neural representations

John J. Vastola

Animals' internal states reflect variables like their position in space, orientation, decisions, and motor actions -- but how should these internal states be arranged? Internal sta…

cs.LG2025

Dynamical symmetries in the fluctuation-driven regime: an application of Noether's theorem to noisy dynamical systems

John J. Vastola

Noether's theorem provides a powerful link between continuous symmetries and conserved quantities for systems governed by some variational principle. Perhaps unfortunately, most dy…

cs.LG2024

The Unreasonable Effectiveness of Gaussian Score Approximation for Diffusion Models and its Applications

Binxu Wang, John J. Vastola

By learning the gradient of smoothed data distributions, diffusion models can iteratively generate samples from complex distributions. The learned score function enables their gene…

cs.AI2023

The Hidden Linear Structure in Score-Based Models and its Application

Binxu Wang, John J. Vastola

Score-based models have achieved remarkable results in the generative modeling of many domains. By learning the gradient of smoothed data distribution, they can iteratively generat…

cs.CV2023★ 1 cited

Diffusion Models Generate Images Like Painters: an Analytical Theory of Outline First, Details Later

Binxu Wang, John J. Vastola

How do diffusion generative models convert pure noise into meaningful images? In a variety of pretrained diffusion models (including conditional latent space models like Stable Dif…

q-bio.SC2021★ 6 cited

Analytic solution of chemical master equations involving gene switching. I: Representation theory and diagrammatic approach to exact solution

John J. Vastola, Gennady Gorin, Lior Pachter +1

The chemical master equation (CME), which describes the discrete and stochastic molecule number dynamics associated with biological processes like transcription, is difficult to so…

q-bio.QM2019★ 2 cited

Solving the chemical master equation for monomolecular reaction systems analytically: a Doi-Peliti path integral view

John J. Vastola

The chemical master equation (CME) is a fundamental description of interacting molecules commonly used to model chemical kinetics and noisy gene regulatory networks. Exact time-dep…

cond-mat.stat-mech2019★ 3 cited

The chemical birth-death process with Gillespie noise

John J. Vastola

A nontrivial technical issue has long plagued the literature on stochastic path integrals: it is not clear which definition is correct in the case of multiplicative/state-dependent…

q-bio.QM2019★ 5 cited

The chemical birth-death process with additive noise

John J. Vastola

The chemical birth-death process, whose chemical master equation (CME) is exactly solvable, is a paradigmatic toy problem often used to get intuition for how stochasticity affects…

q-bio.QM2019★ 10 cited

The chemical Langevin equation: a path integral view of Gillespie's derivation

John J. Vastola, William R. Holmes

In 2000, Gillespie rehabilitated the chemical Langevin equation (CLE) by describing two conditions that must be satisfied for it yield a valid approximation of the chemical master…

cond-mat.stat-mech2019★ 8 cited

Stochastic path integrals can be derived like quantum mechanical path integrals

John J. Vastola, William R. Holmes

Stochastic mechanics---the study of classical stochastic systems governed by things like master equations and Fokker-Planck equations---exhibits striking mathematical parallels to…