56 citations · 209 across the 11 of their papers we have counts for
5 papers · 1 filter
Intermolecular correlations are necessary to explain diffuse scattering from protein crystals
Ariana Peck, Frédéric Poitevin, Thomas J. Lane
Conformational changes drive protein function, including catalysis, allostery, and signaling. X-ray diffuse scattering from protein crystals has frequently been cited as a probe of…
A Flexible Phase Retrieval Framework for Flux-limited Coherent X-Ray Imaging
Liang Shi, Gordon Wetzstein, Thomas J. Lane
Coherent X-ray diffraction imaging (CXDI) experiments are intrinsically limited by shot noise, a lack of prior knowledge about the sample's support, and missing measurements due to…
Efficient inference of protein structural ensembles
Thomas J. Lane, Christian R. Schwantes, Kyle A. Beauchamp +1
It is becoming clear that traditional, single-structure models of proteins are insufficient for understanding their biological function. Here, we outline one method for inferring,…
Probing the Origins of Two-State Folding
Thomas J. Lane, Christian R. Schwantes, Kyle A. Beauchamp +1
Many protein systems fold in a two-state manner. Random models, however, rarely display two-state kinetics and thus such behavior should not be accepted as a default. To date, many…
Eigenvalues of the Homogeneous Finite Linear One Step Master Equation: Applications to Downhill Folding
Thomas Lane, Vijay Pande
Motivated by claims about the nature of the observed timescales in protein systems said to fold downhill, we have studied the finite, linear master equation which is a model of the…