261 citations · 1.1k across the 9 of their papers we have counts for
4 papers · 1 filter
Population variability in the generation and thymic selection of T-cell repertoires
Zachary Sethna, Giulio Isacchini, Thomas Dupic +3
The diversity of T-cell receptor (TCR) repertoires is achieved by a combination of two intrinsically stochastic steps: random receptor generation by VDJ recombination, and selectio…
Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires
Mikhail V. Pogorelyy, Yuval Elhanati, Quentin Marcou +9
The diversity of T-cell receptors recognizing foreign pathogens is generated through a highly stochastic recombination process, making the independent production of the same sequen…
Inferring processes underlying B-cell repertoire diversity
Yuval Elhanati, Zachary Sethna, Quentin Marcou +3
We quantify the VDJ recombination and somatic hypermutation processes in human B-cells using probabilistic inference methods on high-throughput DNA sequence repertoires of human B-…
Quantifying selection in immune receptor repertoires
Yuval Elhanati, Anand Murugan, Curtis G. Callan +2
The efficient recognition of pathogens by the adaptive immune system relies on the diversity of receptors displayed at the surface of immune cells. T-cell receptor diversity result…