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q-bio.BM2022★ 1 cited
AlphaFold2 can predict single-mutation effects
John M. McBride, Konstantin Polev, Amirbek Abdirasulov +3
AlphaFold2 (AF) is a promising tool, but is it accurate enough to predict single mutation effects? Here, we report that the localized structural deformation between protein pairs d…
q-bio.BM2019
DCA method identifies unspecific binding but specific disruption of the group I intron by the StpA chaperone
Vladimir Reinharz, Tsvi Tlusty
Chaperone protein - the most disordered among all protein groups - help RNAs fold into their functional structure by destabilizing misfolded configurations or stabilizing the funct…