75 citations · 128 across the 6 of their papers we have counts for
6 papers
SMART: Spatial Modeling Algorithms for Reaction and Transport
Justin G. Laughlin, Jørgen S. Dokken, Henrik N. T. Finsberg +4
Recent advances in microscopy and 3D reconstruction methods have allowed for characterization of cellular morphology in unprecedented detail, including the irregular geometries of…
Mem3DG: Modeling Membrane Mechanochemical Dynamics in 3D using Discrete Differential Geometry
Cuncheng Zhu, Christopher T. Lee, Padmini Rangamani
Biomembranes adopt varying morphologies that are vital to cellular functions. Many studies use computational modeling to understand how various mechanochemical factors contribute t…
Applications and Challenges of Machine Learning to Enable Realistic Cellular Simulations
Ritvik Vasan, Meagan P. Rowan, Christopher T. Lee +3
In this perspective, we examine three key aspects of an end-to-end pipeline for realistic cellular simulations: reconstruction and segmentation of cellular structures; generation o…
An Open Source Mesh Generation Platform for Biophysical Modeling Using Realistic Cellular Geometries
Christopher T. Lee, Justin G. Laughlin, John B. Moody +4
Advances in imaging methods such as electron microscopy, tomography and other modalities are enabling high-resolution reconstructions of cellular and organelle geometries. Such adv…
3D mesh processing using GAMer 2 to enable reaction-diffusion simulations in realistic cellular geometries
Christopher T. Lee, Justin G. Laughlin, Nils Angliviel de La Beaumelle +5
Recent advances in electron microscopy have enabled the imaging of single cells in 3D at nanometer length scale resolutions. An uncharted frontier for in silico biology is the abil…
The Implementation of the Colored Abstract Simplicial Complex and its Application to Mesh Generation
C. T. Lee, J. B. Moody, R. E. Amaro +2
We introduce CASC: a new, modern, and header-only C++ library which provides a data structure to represent arbitrary dimension abstract simplicial complexes (ASC) with user-defined…