36 citations · 76 across the 13 of their papers we have counts for
6 papers · 1 filter
Effective Biological Representation Learning by Masking Gene Expression
Kian Kenyon-Dean, Alina Selega, Ihab Bendidi +5
RNA sequencing produces rich and diverse datasets of gene expression, offering compelling insights into cellular state and function that have many applications in drug discovery. M…
A Cross Modal Knowledge Distillation & Data Augmentation Recipe for Improving Transcriptomics Representations through Morphological Features
Ihab Bendidi, Yassir El Mesbahi, Alisandra K. Denton +4
Understanding cellular responses to stimuli is crucial for biological discovery and drug development. Transcriptomics provides interpretable, gene-level insights, while microscopy…
Towards scientific discovery with dictionary learning: Extracting biological concepts from microscopy foundation models
Konstantin Donhauser, Kristina Ulicna, Gemma Elyse Moran +4
Sparse dictionary learning (DL) has emerged as a powerful approach to extract semantically meaningful concepts from the internals of large language models (LLMs) trained mainly in…
Benchmarking Transcriptomics Foundation Models for Perturbation Analysis : one PCA still rules them all
Ihab Bendidi, Shawn Whitfield, Kian Kenyon-Dean +4
Understanding the relationships among genes, compounds, and their interactions in living organisms remains limited due to technological constraints and the complexity of biological…
ViTally Consistent: Scaling Biological Representation Learning for Cell Microscopy
Kian Kenyon-Dean, Zitong Jerry Wang, John Urbanik +10
Large-scale cell microscopy screens are used in drug discovery and molecular biology research to study the effects of millions of chemical and genetic perturbations on cells. To us…
Clustering-Oriented Representation Learning with Attractive-Repulsive Loss
Kian Kenyon-Dean, Andre Cianflone, Lucas Page-Caccia +3
The standard loss function used to train neural network classifiers, categorical cross-entropy (CCE), seeks to maximize accuracy on the training data; building useful representatio…