4 papers
Simulating the chromatin mediated phase separation of model proteins with multiple domains
Marco Ancona, Chris A. Brackley
We perform simulations of a system containing simple model proteins and a polymer representing chromatin. We study the interplay between protein-protein and protein-chromatin inter…
Emergence of effective temperatures in an out-of-equilibrium model of biopolymer folding
Marco Ancona, Alessandro Bentivoglio, Michele Caraglio +2
We investigate the possibility of extending the notion of temperature in a stochastic model for the RNA/protein folding driven out of equilibrium. We simulate the dynamics of a sma…
Competition between local erasure and long-range spreading of a single biochemical mark leads to epigenetic bistability
Marco Ancona, Davide Michieletto, Davide Marenduzzo
The mechanism through which cells determine their fate is intimately related to the spreading of certain biochemical (so-called epigenetic) marks along their genome. The mechanisms…
Transcriptional bursts in a non-equilibrium model for gene regulation by supercoiling
Marco Ancona, Alessandro Bentivoglio, Chris A. Brackley +2
We analyse transcriptional bursting within a stochastic non-equilibrium model which accounts for the coupling between the dynamics of DNA supercoiling and gene transcription. We fi…