activity
20192026
most citedA Systematic Bias of Machine Learning Regression Models and Its Correction: an Application to Imaging-based Brain Age Prediction

3 citations · 5 across the 9 of their papers we have counts for

collaborators

9 papers

stat.AP2026

Trustworthy AI/ML Regression and Unbiased Causal Inference for Real-World Data

Yifei Xu, Hwiyoung Lee, Zhenyao Ye +5

Real-World Data (RWD), with its large sample sizes and rich clinical detail, offers a compelling alternative to randomized controlled trials (RCTs) for studying treatment effects i…

stat.ME2026

Outcome-Calibrated Regression and Predicted Outcome-Based Inference

Hwiyoung Lee, Shuo Chen

Regression is a fundamental tool in scientific research. Ordinary least squares (OLS), one of the most widely used regression methods, enjoys several desirable properties, includin…

stat.ME2025

Modeling Dependence in Omics Association Analysis via Structured Co-Expression Networks to Improve Power and Replicability

Hwiyoung Lee, Yezhi Pan, Shuo Chen

Accounting for dependence among high-dimensional variables in omics data analysis is critical to obtain accurate and reliable statistical inference. Although latent, omics variable…

stat.ML2025

Graph Canonical Correlation Analysis

Hongju Park, Shuyang Bai, Zhenyao Ye +3

Canonical correlation analysis (CCA) is a widely used technique for estimating associations between two sets of multi-dimensional variables. Recent advancements in CCA methods have…

stat.ML2024★ 3 cited

A Systematic Bias of Machine Learning Regression Models and Its Correction: an Application to Imaging-based Brain Age Prediction

Hwiyoung Lee, Shuo Chen

Machine learning models for continuous outcomes often yield systematically biased predictions, particularly for values that largely deviate from the mean. Specifically, predictions…

stat.ME2024

Modeling Interconnected Modules in Multivariate Outcomes: Evaluating the Impact of Alcohol Intake on Plasma Metabolomics

Yifan Yang, Chixiang Chen, Hwiyoung Lee +2

Alcohol consumption has been shown to influence cardiovascular mechanisms in humans, leading to observable alterations in the plasma metabolomic profile. Regression models are comm…

stat.ME2021★ 1 cited

Robust Extrinsic Regression Analysis for Manifold Valued Data

Hwiyoung Lee

Recently, there has been a growing need in analyzing data on manifolds owing to their important role in diverse fields of science and engineering. In the literature of manifold-val…

stat.ML2019

Extrinsic Kernel Ridge Regression Classifier for Planar Kendall Shape Space

Hwiyoung Lee, Vic Patrangenaru

Kernel methods have had great success in Statistics and Machine Learning. Despite their growing popularity, however, less effort has been drawn towards developing kernel based clas…

math.ST2019★ 1 cited

Anti-MANOVA on Compact Manifolds with Applications to 3D Projective Shape Analysis

Hwiyoung Lee, Vic Patrangenaru

Methods of hypotheses testing for equality of extrinsic antimeans on compact manifolds are unveiled in this paper. The two and multiple sample problem for antimeans on compact mani…