1.3k citations · 1.5k across the 6 of their papers we have counts for
6 papers
Sloppiness and Emergent Theories in Physics, Biology, and Beyond
Mark K. Transtrum, Benjamin Machta, Kevin Brown +3
Large scale models of physical phenomena demand the development of new statistical and computational tools in order to be effective. Many such models are `sloppy', i.e., exhibit be…
Universally Sloppy Parameter Sensitivities in Systems Biology
Ryan N. Gutenkunst, Joshua J. Waterfall, Fergal P. Casey +3
Quantitative computational models play an increasingly important role in modern biology. Such models typically involve many free parameters, and assigning their values is often a s…
Optimal experimental design in an EGFR signaling and down-regulation model
Fergal P. Casey, Dan Baird, Qiyu Feng +6
We apply the methods of optimal experimental design to a differential equation model for epidermal growth factor receptor (EGFR) signaling, trafficking, and down-regulation. The mo…
The sloppy model universality class and the Vandermonde matrix
Joshua J. Waterfall, Fergal P. Casey, Ryan N. Gutenkunst +5
In a variety of contexts, physicists study complex, nonlinear models with many unknown or tunable parameters to explain experimental data. We explain why such systems so often are…
Solving the phase problem in i(AlPdMn)
K. S. Brown, A. A. Avanesov, V. Elser
We apply a new technique for ab initio phase determination [Acta Crystallogr. Sect. A, A55, 48 (1999)] to solve for the average structure of the icosahedral (i) phase of AlPdMn. Af…
Mean-Field Analysis and Monte Carlo Study of an Interacting Two-Species Catalytic Surface Reaction Model
Kevin Scott Brown, Kevin E. Bassler, Dana A. Browne
We study the phase diagram and critical behavior of an interacting one dimensional two species monomer-monomer catalytic surface reaction model with a reactive phase as well as two…