activity
20132022
most citedSecond-generation PLINK: rising to the challenge of larger and richer datasets

14.3k citations · 14.4k across the 6 of their papers we have counts for

collaborators

6 papers

cs.CY2022★ 2 cited

Interpretable (not just posthoc-explainable) medical claims modeling for discharge placement to prevent avoidable all-cause readmissions or death

Joshua C. Chang, Ted L. Chang, Carson C. Chow +5

We developed an inherently interpretable multilevel Bayesian framework for representing variation in regression coefficients that mimics the piecewise linearity of ReLU-activated d…

cs.LG2020★ 2 cited

Sparse encoding for more-interpretable feature-selecting representations in probabilistic matrix factorization

Joshua C. Chang, Patrick Fletcher, Jungmin Han +5

Dimensionality reduction methods for count data are critical to a wide range of applications in medical informatics and other fields where model interpretability is paramount. For…

cs.LG2019★ 4 cited

Probabilistically-autoencoded horseshoe-disentangled multidomain item-response theory models

Joshua C. Chang, Shashaank Vattikuti, Carson C. Chow

Item response theory (IRT) is a non-linear generative probabilistic paradigm for using exams to identify, quantify, and compare latent traits of individuals, relative to their peer…

q-bio.NC2018

Multi-scale variability in neuronal competition

Benjamin P Cohen, Carson C Chow, Shashaank Vattikuti

We examine whether a single biophysical cortical circuit model can explain both spiking and perceptual variability. We consider perceptual rivalry, which provides a window into int…

q-bio.GN2014★ 14.3k cited

Second-generation PLINK: rising to the challenge of larger and richer datasets

Christopher C. Chang, Carson C. Chow, Laurent C. A. M. Tellier +3

PLINK 1 is a widely used open-source C/C++ toolset for genome-wide association studies (GWAS) and research in population genetics. However, the steady accumulation of data from imp…

q-bio.GN2013★ 5 cited

Application of compressed sensing to genome wide association studies and genomic selection

Shashaank Vattikuti, James J. Lee, Christopher C. Chang +2

We show that the signal-processing paradigm known as compressed sensing (CS) is applicable to genome-wide association studies (GWAS) and genomic selection (GS). The aim of GWAS is…