3 papers
q-bio.QM2022
Generic Adaptation by Fast Chaotic Exploration and Slow Feedback Fixation
Yuuki Matsushita, Kunihiko Kaneko
Living systems adapt to various environmental conditions by changing their internal states. Inspired by gene expression and epigenetic modification dynamics, we herein propose a ge…
physics.bio-ph2021
Dynamical-systems theory of cellular reprogramming
Yuuki Matsushita, Tetsuhiro S. Hatakeyama, Kunihiko Kaneko
In cellular reprogramming, almost all epigenetic memories of differentiated cells are erased by the overexpression of few genes, regaining pluripotency, potentiality for differenti…
q-bio.MN2019
Homeorhesis in Waddington's Landscape by Epigenetic Feedback Regulation
Yuuki Matsushita, Kunihiko Kaneko
In multicellular organisms, cells differentiate into several distinct types during early development. Determination of each cellular state, along with the ratio of each cell type,…