4 papers
de novo gene birth as an inevitable consequence of adaptive evolution
Somya Mani, Tsvi Tlusty
Phylostratigraphy suggests that new genes are continually born de novo from non-genic sequences, and the genes that persist found new lineages, contributing to the adaptive evoluti…
A topological look into the evolution of developmental programs
Somya Mani, Tsvi Tlusty
Rapid advance of experimental techniques provides an unprecedented in-depth view into complex developmental processes. Still, little is known on how the complexity of multicellular…
Large-Scale Survey of Cell-Differentiation Programs in a Generative Model Reveals Regeneration as an Epiphenomenon of Development
Somya Mani, Tsvi Tlusty
Development combines three basic processes asymmetric --- cell division, signaling and gene regulation --- in a multitude of ways to create an overwhelming diversity of multicellul…
Synthesis for Vesicle Traffic Systems
Ashutosh Gupta, Somya Mani, Ankit Shukla
Vesicle Traffic Systems (VTSs) are the material transport mechanisms among the compartments inside the biological cells. The compartments are viewed as nodes that are labeled with…