most citedSelection Induced Contrast Estimate (SICE) Effect: An Attempt to Quantify the Impact of Some Patient Selection Criteria in Randomized Clinical Trials

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Selection Induced Contrast Estimate (SICE) Effect: An Attempt to Quantify the Impact of Some Patient Selection Criteria in Randomized Clinical Trials

Junshui Ma, Daniel J. Holder

Defining the Inclusion/Exclusion (I/E) criteria of a trial is one of the most important steps during a trial design. Increasingly complex I/E criteria potentially create informatio…