3 citations · 9 across the 3 of their papers we have counts for
3 papers
Adaptive clinical trial designs with blinded selection of binary composite endpoints and sample size reassessment
Marta Bofill Roig, Guadalupe Gómez Melis, Martin Posch +1
For randomized clinical trials where a single, primary, binary endpoint would require unfeasibly large sample sizes, composite endpoints are widely chosen as the primary endpoint.…
Decision tool and Sample Size Calculator for Composite Endpoints
Marta Bofill Roig, Jordi Cortés Martínez, Guadalupe Gómez Melis
Summary points: - This article considers the combination of two binary or two time-to-event endpoints to form the primary composite endpoint for leading a trial. - It discusses the…
Non-constant hazard ratios in randomized controlled trials with composite endpoints
Jordi Cortés Martínez, Moisès Gómez Mateu, KyungMann Kim +1
The hazard ratio is routinely used as a summary measure to assess the treatment effect in clinical trials with time-to-event endpoints. It is frequently assumed as constant over ti…