7 citations · 25 across the 10 of their papers we have counts for
3 papers · 1 filter
Design of Trials with Composite Endpoints with the R Package CompAREdesign
Jordi Cortés Martinez, Marta Bofill Roig, Guadalupe Gómez Melis
Composite endpoints are widely used as primary endpoints in clinical trials. Designing trials with time-to-event endpoints can be particularly challenging because the proportional…
The Online Closure Principle
Lasse Fischer, Marta Bofill Roig, Werner Brannath
The closure principle is fundamental in multiple testing and has been used to derive many efficient procedures with familywise error rate control. However, it is often unsuitable f…
Adaptive clinical trial designs with blinded selection of binary composite endpoints and sample size reassessment
Marta Bofill Roig, Guadalupe Gómez Melis, Martin Posch +1
For randomized clinical trials where a single, primary, binary endpoint would require unfeasibly large sample sizes, composite endpoints are widely chosen as the primary endpoint.…