4 papers
Deciphering the regulatory genome of , one hundred promoters at a time
William T. Ireland, Suzannah M. Beeler, Emanuel Flores-Bautista +5
Advances in DNA sequencing have revolutionized our ability to read genomes. However, even in the most well-studied of organisms, the bacterium , for $\appro…
The Energetics of Molecular Adaptation in Transcriptional Regulation
Griffin Chure, Manuel Razo-Mejia, Nathan M. Belliveau +5
Mutation is a critical mechanism by which evolution explores the functional landscape of proteins. Despite our ability to experimentally inflict mutations at will, it remains diffi…
Figure 1 Theory Meets Figure 2 Experiments in the Study of Gene Expression
Rob Phillips, Nathan M. Belliveau, Griffin Chure +3
It is tempting to believe that we now own the genome. The ability to read and re-write it at will has ushered in a stunning period in the history of science. Nonetheless, there is…
Tuning transcriptional regulation through signaling: A predictive theory of allosteric induction
Manuel Razo-Mejia, Stephanie L. Barnes, Nathan M. Belliveau +4
Allosteric regulation is found across all domains of life, yet we still lack simple, predictive theories that directly link the experimentally tunable parameters of a system to its…