9 papers
Lysine-Cysteine-Serine-Tryptophan Inserted into the DNA-Binding Domain of Human Mineralocorticoid Receptor Increases Transcriptional Activation by Aldosterone
Yoshinao Katsu, Jiawen Zhang, Michael E. Baker
Due to alternative splicing in an ancestral DNA-binding domain (DBD) of the mineralocorticoid receptor (MR), humans contain two almost identical MR transcripts with either 984 amin…
Novel Evolution of the Mineralocorticoid Receptor in Humans compared to Chimpanzees, Gorillas and Orangutans
Yoshinao Katsu, Jiawen Zhang, Michael E. Baker
Five distinct full-length mineralocorticoid receptor (MR) genes have been identified in humans. These human MRs can be distinguished by the presence or absence of an in-frame inser…
Reduced steroid activation of elephant shark glucocorticoid and mineralocorticoid receptors after inserting four amino acids from the DNA-binding domain of lamprey corticoid receptor-1
Yoshinao Katsu, Jiawen Zhang, Michael E. Baker
Atlantic sea lamprey contains two corticoid receptors (CRs), CR1 and CR2, that are identical except for a four amino acid insert (Thr-Arg-Gln-Gly) in the CR1 DNA-binding domain (DB…
Corticosteroid Activation of Atlantic Sea Lamprey Corticoid Receptor: Allosteric Regulation by the N-terminal Domain
Yoshinao Katsu, Xiaozhi Lin, Ruigeng Ji +4
Lampreys are jawless fish that evolved about 550 million years ago at the base of the vertebrate line. Modern lampreys contain a corticoid receptor (CR), the common ancestor of the…
Aldosterone and Dexamethasone Activate African Lungfish Mineralocorticoid Receptor: Increased Activation After Removal of the Amino-Terminal Domain
Yoshinao Katsu, Shin Oana, Xiaozhi Lin +2
Aldosterone, the main physiological mineralocorticoid in humans and other terrestrial vertebrates, first appears in lungfish, which are lobe-finned fish that are forerunners of ter…
Regulation by Progestins, Corticosteroids and RU486 of Activation of Elephant Shark and Human Progesterone Receptors: An Evolutionary Perspec
Xiaozhi Lin, Wataru Takagi, Susumu Hyodo +3
We investigated progestin and corticosteroid activation of the progesterone receptor (PR) from elephant shark (Callorhinchus milii), a cartilaginous fish belonging to the oldest gr…
Progesterone: An Enigmatic Ligand for the Mineralocorticoid Receptor
Michael E. Baker, Yoshinao Katsu
The progesterone receptor (PR) mediates progesterone regulation of female reproductive physiology, as well as gene transcription in non-reproductive tissues, such as brain, bone, l…
N-terminal domain Increases Activation of Elephant Shark Glucocorticoid and Mineralocorticoid Receptors
Yoshinao Katsu, Islam MD Shariful, Xiaozhi Lin +5
Cortisol, corticosterone and aldosterone activate full-length glucocorticoid receptor (GR) from elephant shark, a cartilaginous fish belonging to the oldest group of jawed vertebra…
Transcriptional Activation of Elephant Shark Mineralocorticoid Receptor by Corticosteroids, Progesterone and Spironolactone
Yoshinao Katsu, Satomi Kohno, Kaori Oka +7
We report the analysis of activation by corticosteroids and progesterone of full-length mineralocorticoid receptor (MR) from elephant shark, a cartilaginous fish belonging to the o…