6 papers
Corticosteroid Activation of Atlantic Sea Lamprey Corticoid Receptor: Allosteric Regulation by the N-terminal Domain
Yoshinao Katsu, Xiaozhi Lin, Ruigeng Ji +4
Lampreys are jawless fish that evolved about 550 million years ago at the base of the vertebrate line. Modern lampreys contain a corticoid receptor (CR), the common ancestor of the…
Aldosterone and Dexamethasone Activate African Lungfish Mineralocorticoid Receptor: Increased Activation After Removal of the Amino-Terminal Domain
Yoshinao Katsu, Shin Oana, Xiaozhi Lin +2
Aldosterone, the main physiological mineralocorticoid in humans and other terrestrial vertebrates, first appears in lungfish, which are lobe-finned fish that are forerunners of ter…
Regulation by Progestins, Corticosteroids and RU486 of Activation of Elephant Shark and Human Progesterone Receptors: An Evolutionary Perspec
Xiaozhi Lin, Wataru Takagi, Susumu Hyodo +3
We investigated progestin and corticosteroid activation of the progesterone receptor (PR) from elephant shark (Callorhinchus milii), a cartilaginous fish belonging to the oldest gr…
Progesterone: An Enigmatic Ligand for the Mineralocorticoid Receptor
Michael E. Baker, Yoshinao Katsu
The progesterone receptor (PR) mediates progesterone regulation of female reproductive physiology, as well as gene transcription in non-reproductive tissues, such as brain, bone, l…
N-terminal domain Increases Activation of Elephant Shark Glucocorticoid and Mineralocorticoid Receptors
Yoshinao Katsu, Islam MD Shariful, Xiaozhi Lin +5
Cortisol, corticosterone and aldosterone activate full-length glucocorticoid receptor (GR) from elephant shark, a cartilaginous fish belonging to the oldest group of jawed vertebra…
Transcriptional Activation of Elephant Shark Mineralocorticoid Receptor by Corticosteroids, Progesterone and Spironolactone
Yoshinao Katsu, Satomi Kohno, Kaori Oka +7
We report the analysis of activation by corticosteroids and progesterone of full-length mineralocorticoid receptor (MR) from elephant shark, a cartilaginous fish belonging to the o…