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Distinguishing Mechanisms Underlying EMT Tristability
Dongya Jia, Mohit Kumar Jolly, Satyendra C. Tripathi +10
Background: The Epithelial-Mesenchymal Transition (EMT) endows epithelial-looking cells with enhanced migratory ability during embryonic development and tissue repair. EMT can also…
Implications of the hybrid epithelial/mesenchymal phenotype in metastasis
Mohit Kumar Jolly, Marcelo Boareto, Bin Huang +5
Understanding cell-fate decisions during tumorigenesis and metastasis is a major challenge in modern cancer biology. One canonical cell-fate decision that cancer cells undergo is E…
Self-assisted Amoeboid Navigation in Complex Environments
Inbal Hecht, Herbert Levine, Wouter-Jan Rappel +1
Background: Living cells of many types need to move in response to external stimuli in order to accomplish their functional tasks; these tasks range from wound healing to immune re…
Coexistence of amplitude and frequency modulations in intracellular calcium dynamics
Maurizio De Pitta, Vladislav Volman, Herbert Levine +3
The complex dynamics of intracellular calcium regulates cellular responses to information encoded in extracellular signals. Here, we study the encoding of these external signals in…
Physical Schemata Underlying Biological Pattern Formation - Examples, Issues and Strategies
Herbert Levine, Eshel Ben-Jacob
Biological systems excel at building spatial structures on scales ranging from nanometers to kilometers and exhibit temporal patterning from milliseconds to years. One approach tha…