activity
20182025
most citedDeep Learning-enabled Virtual Histological Staining of Biological Samples

354 citations · 1.6k across the 30 of their papers we have counts for

collaborators

30 papers

cs.CV2025

Autonomous labeling of surgical resection margins using a foundation model

Xilin Yang, Musa Aydin, Yuhong Lu +9

Assessing resection margins is central to pathological specimen evaluation and has profound implications for patient outcomes. Current practice employs physical inking, which is ap…

physics.optics2024

Lying mirror using structured surfaces

Yuhang Li, Shiqi Chen, Bijie Bai +1

We introduce an all-optical system, termed the "lying mirror", to hide input information by transforming it into misleading, ordinary-looking patterns that effectively camouflage t…

eess.IV2024★ 35 cited

Automated HER2 Scoring in Breast Cancer Images Using Deep Learning and Pyramid Sampling

Sahan Yoruc Selcuk, Xilin Yang, Bijie Bai +12

Human epidermal growth factor receptor 2 (HER2) is a critical protein in cancer cell growth that signifies the aggressiveness of breast cancer (BC) and helps predict its prognosis.…

physics.med-ph2024★ 26 cited

Virtual birefringence imaging and histological staining of amyloid deposits in label-free tissue using autofluorescence microscopy and deep learning

Xilin Yang, Bijie Bai, Yijie Zhang +8

Systemic amyloidosis is a group of diseases characterized by the deposition of misfolded proteins in various organs and tissues, leading to progressive organ dysfunction and failur…

physics.optics2024★ 19 cited

Multiplexed all-optical permutation operations using a reconfigurable diffractive optical network

Guangdong Ma, Xilin Yang, Bijie Bai +8

Large-scale and high-dimensional permutation operations are important for various applications in e.g., telecommunications and encryption. Here, we demonstrate the use of all-optic…

physics.optics2024★ 33 cited

Subwavelength Imaging using a Solid-Immersion Diffractive Optical Processor

Jingtian Hu, Kun Liao, Niyazi Ulas Dinc +14

Phase imaging is widely used in biomedical imaging, sensing, and material characterization, among other fields. However, direct imaging of phase objects with subwavelength resoluti…

physics.optics2024★ 38 cited

Information hiding cameras: optical concealment of object information into ordinary images

Bijie Bai, Ryan Lee, Yuhang Li +4

Data protection methods like cryptography, despite being effective, inadvertently signal the presence of secret communication, thereby drawing undue attention. Here, we introduce a…

physics.optics2023★ 26 cited

Complex-valued universal linear transformations and image encryption using spatially incoherent diffractive networks

Xilin Yang, Md Sadman Sakib Rahman, Bijie Bai +2

As an optical processor, a Diffractive Deep Neural Network (D2NN) utilizes engineered diffractive surfaces designed through machine learning to perform all-optical information proc…

physics.optics2023★ 31 cited

Pyramid diffractive optical networks for unidirectional image magnification and demagnification

Bijie Bai, Xilin Yang, Tianyi Gan +4

Diffractive deep neural networks (D2NNs) are composed of successive transmissive layers optimized using supervised deep learning to all-optically implement various computational ta…

physics.bio-ph2023★ 1 cited

Lab-in-a-Tube: A portable imaging spectrophotometer for cost-effective, high-throughput, and label-free analysis of centrifugation processes

Yuanyuan Wei, Dehua Hu, Bijie Bai +7

Centrifuges serve as essential instruments in modern experimental sciences, facilitating a wide range of routine sample processing tasks that necessitate material sedimentation. Ho…

physics.optics2023★ 24 cited

Broadband nonlinear modulation of incoherent light using a transparent optoelectronic neuron array

Dehui Zhang, Dong Xu, Yuhang Li +14

Nonlinear optical processing of ambient natural light is highly desired in computational imaging and sensing applications. A strong optical nonlinear response that can work under w…

physics.optics2023★ 20 cited

Optical information transfer through random unknown diffusers using electronic encoding and diffractive decoding

Yuhang Li, Tianyi Gan, Bijie Bai +3

Free-space optical information transfer through diffusive media is critical in many applications, such as biomedical devices and optical communication, but remains challenging due…

physics.optics2023★ 68 cited

Universal Linear Intensity Transformations Using Spatially-Incoherent Diffractive Processors

Md Sadman Sakib Rahman, Xilin Yang, Jingxi Li +2

Under spatially-coherent light, a diffractive optical network composed of structured surfaces can be designed to perform any arbitrary complex-valued linear transformation between…

physics.optics2023★ 9 cited

Roadmap on Deep Learning for Microscopy

Giovanni Volpe, Carolina Wählby, Lei Tian +72

Through digital imaging, microscopy has evolved from primarily being a means for visual observation of life at the micro- and nano-scale, to a quantitative tool with ever-increasin…

physics.optics2023★ 37 cited

Quantitative phase imaging (QPI) through random diffusers using a diffractive optical network

Yuhang Li, Yi Luo, Deniz Mengu +2

Quantitative phase imaging (QPI) is a label-free computational imaging technique used in various fields, including biology and medical research. Modern QPI systems typically rely o…

physics.optics2022★ 59 cited

Data class-specific all-optical transformations and encryption

Bijie Bai, Heming Wei, Xilin Yang +2

Diffractive optical networks provide rich opportunities for visual computing tasks since the spatial information of a scene can be directly accessed by a diffractive processor with…

physics.optics2022★ 57 cited

Unidirectional Imaging using Deep Learning-Designed Materials

Jingxi Li, Tianyi Gan, Yifan Zhao +5

A unidirectional imager would only permit image formation along one direction, from an input field-of-view (FOV) A to an output FOV B, and in the reverse path, the image formation…

physics.med-ph2022★ 354 cited

Deep Learning-enabled Virtual Histological Staining of Biological Samples

Bijie Bai, Xilin Yang, Yuzhu Li +3

Histological staining is the gold standard for tissue examination in clinical pathology and life-science research, which visualizes the tissue and cellular structures using chromat…

cs.NE2022★ 90 cited

Massively Parallel Universal Linear Transformations using a Wavelength-Multiplexed Diffractive Optical Network

Jingxi Li, Bijie Bai, Yi Luo +1

We report deep learning-based design of a massively parallel broadband diffractive neural network for all-optically performing a large group of arbitrarily-selected, complex-valued…

physics.optics2022★ 70 cited

All-optical image classification through unknown random diffusers using a single-pixel diffractive network

Yi Luo, Bijie Bai, Yuhang Li +2

Classification of an object behind a random and unknown scattering medium sets a challenging task for computational imaging and machine vision fields. Recent deep learning-based ap…

physics.med-ph2022★ 44 cited

Virtual stain transfer in histology via cascaded deep neural networks

Xilin Yang, Bijie Bai, Yijie Zhang +4

Pathological diagnosis relies on the visual inspection of histologically stained thin tissue specimens, where different types of stains are applied to bring contrast to and highlig…

eess.IV2022★ 28 cited

Virtual staining of defocused autofluorescence images of unlabeled tissue using deep neural networks

Yijie Zhang, Luzhe Huang, Tairan Liu +5

Deep learning-based virtual staining was developed to introduce image contrast to label-free tissue sections, digitally matching the histological staining, which is time-consuming,…

physics.ins-det2022★ 56 cited

Rapid and stain-free quantification of viral plaque via lens-free holography and deep learning

Tairan Liu, Yuzhu Li, Hatice Ceylan Koydemir +8

We present a rapid and stain-free quantitative viral plaque assay using lensfree holographic imaging and deep learning. This cost-effective, compact, and automated device significa…

physics.optics2022★ 88 cited

To image, or not to image: Class-specific diffractive cameras with all-optical erasure of undesired objects

Bijie Bai, Yi Luo, Tianyi Gan +6

Privacy protection is a growing concern in the digital era, with machine vision techniques widely used throughout public and private settings. Existing methods address this growing…