3 papers
q-bio.BM2020
State dependent effects on the frequency response of prestin real and imaginary components of nonlinear capacitance
Joseph Santos-Sacchi, Dhasakumar Navaratnam, Winston Tan
The outer hair cell (OHC) membrane harbors a voltage-dependent protein, prestin (SLC26a5), in high density, whose charge movement is evidenced as a nonlinear capacitance (NLC). NLC…
physics.bio-ph2020
Complex nonlinear capacitance in outer hair cell macro-patches: effects of membrane tension
Joseph Santos-Sacchi, Winston Tan
Outer hair cell (OHC) nonlinear capacitance (NLC) represents voltage sensor charge movements of prestin (SLC26a5), the protein responsible for OHC electromotility. Previous measure…
physics.bio-ph2018
The outer hair cell of the organ of Corti possesses a voltage-dependent motile frequency response: evidence for the frequency-dependent compliance of prestin
Joseph Santos-Sacchi, Kuni Iwasa, Winston Tan
The outer hair cell (OHC) of the organ of Corti underlies a mechanically based process that enhances hearing, termed cochlear amplification. The cell possesses a unique motor prote…