24 citations · 39 across the 4 of their papers we have counts for
4 papers
Mechanical compression regulates tumor spheroid invasion into a 3D collagen matrix
Mrinal Pandey, Young Joon Suh, Minha Kim +3
Uncontrolled growth of tumor cells in confined spaces leads to the accumulation of compressive stress within the tumor. Although the effects of tension within 3D extracellular matr…
Tumor Spheroid Chemotaxis in Epidermal Growth Factor Gradients Revealed by a 3D Microfluidic Device
Young Joon Suh, Mrinal Pandey, Jeffrey E Segall +1
Epidermal growth factor (EGF), a potent cytokine, is known to promote tumor invasion both in vivo and in vitro. Previously, we observed that single breast tumor cells (MDA-MB-231 c…
Spatial and temporal dynamics of RhoA activities of single breast tumor cells in a 3D environment revealed by a machine learning-assisted FRET technique
Brian CH Cheung, Louis Hodgson, Jeffrey E Segall +1
One of the hallmarks of cancer cells is their exceptional ability to migrate within the extracellular matrix (ECM) for gaining access to the circulatory system, a critical step of…
The architecture of co-culture spheroids regulates tumor invasion within a 3D extracellular matrix
Yu Ling Huang, Carina Shiau, Cindy Wu +2
Tumor invasion, the process by which tumor cells break away from their primary tumor and gain access to vascular systems, is an important step in cancer metastasis. Most current 3D…