2 papers
q-bio.BM2024
Protein Evolution as a Complex System
Barnabas Gall, Sacha B. Pulsford, Dana Matthews +7
Protein evolution underpins life, and understanding its behavior as a system is of great importance. However, our current models of protein evolution are arguably too simplistic to…
q-bio.PE2024
Computational and Experimental Exploration of Protein Fitness Landscapes: Navigating Smooth and Rugged Terrains
Mahakaran Sandhu, John Chen, Dana Matthews +6
Proteins evolve through complex sequence spaces, with fitness landscapes serving as a conceptual framework that links sequence to function. Fitness landscapes can be smooth, where…