2 papers
stat.ML2024
Bayesian Optimization of Antibodies Informed by a Generative Model of Evolving Sequences
Alan Nawzad Amin, Nate Gruver, Yilun Kuang +6
To build effective therapeutics, biologists iteratively mutate antibody sequences to improve binding and stability. Proposed mutations can be informed by previous measurements or b…
cs.LG2024
Generative Humanization for Therapeutic Antibodies
Cade Gordon, Aniruddh Raghu, Peyton Greenside +1
Antibody therapies have been employed to address some of today's most challenging diseases, but must meet many criteria during drug development before reaching a patient. Humanizat…