1.3k citations · 2.1k across the 15 of their papers we have counts for
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Principled type I error rate inflation in two-arm clinical trial designs with external control information borrowing
Silvia Calderazzo, Manuel Wiesenfarth, Vivienn Weru +1
External information borrowing is often considered in order to improve a clinical trial's efficiency. The Bayesian approach borrows such external information by specifying an infor…
Information borrowing in Bayesian clinical trials: choice of tuning parameters for the robust mixture prior
Vivienn Weru, Annette Kopp-Schneider, Manuel Wiesenfarth +2
External data borrowing in clinical trial designs has increased in recent years. This is accomplished in the Bayesian framework by specifying informative prior distributions. To mi…
Simulating and reporting frequentist operating characteristics of clinical trials that borrow external information
Annette Kopp-Schneider, Manuel Wiesenfarth, Leonhard Held +1
Borrowing of information from historical or external data to inform inference in a current trial is an expanding field in the era of precision medicine, where trials are often perf…
Robust incorporation of historical information with known type I error rate inflation
Silvia Calderazzo, Annette Kopp-Schneider
Bayesian clinical trials can benefit of available historical information through the elicitation of informative prior distributions. Concerns are however often raised about the pot…
Decomposition of Explained Variation in the Linear Mixed Model
Nicholas Schreck, Manuel Wiesenfarth
In the linear mixed model (LMM), the simultaneous assessment and comparison of dispersion relevance of explanatory variables associated with fixed and random effects remains an imp…