98 citations · 118 across the 6 of their papers we have counts for
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In distributive phosphorylation catalytic constants enable non-trivial dynamics
Carsten Conradi, Maya Mincheva
Ordered distributive double phosphorylation is a recurrent motif in intracellular signaling and control. It is either sequential (where the site phosphorylated last is dephosphoryl…
On the existence of Hopf bifurcations in the sequential and distributive double phosphorylation cycle
Carsten Conradi, Elisenda Feliu, Maya Mincheva
Protein phosphorylation cycles are important mechanisms of the post translational modification of a protein and as such an integral part of intracellular signaling and control. We…
Emergence of oscillations in a mixed-mechanism phosphorylation system
Carsten Conradi, Maya Mincheva, Anne Shiu
This work investigates the emergence of oscillations in one of the simplest cellular signaling networks exhibiting oscillations, namely, the dual-site phosphorylation and dephospho…
Identifying parameter regions for multistationarity
Carsten Conradi, Elisenda Feliu, Maya Mincheva +1
Mathematical modelling has become an established tool for studying the dynamics of biological systems. Current applications range from building models that reproduce quantitative d…
Graph-theoretic analysis of multistationarity using degree theory
Carsten Conradi, Maya Mincheva
Biochemical mechanisms with mass action kinetics are often modeled by systems of polynomial differential equations (DE). Determining directly if the DE system has multiple equilibr…