activity
20162026
most citedNonlinear cancer chemotherapy: modelling the Norton-Simon hypothesis

25 citations · 69 across the 11 of their papers we have counts for

collaborators

12 papers

nlin.CD2026

The thermodynamic efficiency of coupled chaotic dissipative structures

Álvaro G. López, Inés P. Mariño, Alfonso Delgado-Bonal

Dissipative structures are open dynamical systems that sustain coherent macroscopic organization by continuously exchanging energy and matter with their environment and generating…

quant-ph2023★ 1 cited

Contextuality and correlation loopholes are equivalent

Álvaro García López

We show that contextual hidden variables including the effect of the measuring devices can be backward-propagated by means of the Green's function to initial Cauchy hidden data. If…

nlin.CD2021★ 5 cited

Ergodic decay laws in Newtonian and relativistic chaotic scattering

Diego S. Fernández, Álvaro G. López, Jesús M. Seoane +1

In open Hamiltonian systems, the escape from a bounded region of phase space according to an exponential decay law is frequently associated with the existence of hyperbolic dynamic…

physics.plasm-ph2020★ 4 cited

Average conservative chaos in quantum dusty plasmas

Álvaro G. López, Rustam Ali, Laxmikanta Mandi +1

We consider a hydrodynamic model of a quantum dusty plasma. We prove mathematically that the resulting dust ion acoustic plasma waves present the property of being conservative on…

nlin.CD2020★ 6 cited

Transient chaos under coordinate transformations in relativistic systems

D. S. Fernández, Á. G. López, J. M. Seoane +1

We use the Hénon-Heiles system as a paradigmatic model for chaotic scattering to study the Lorentz factor effects on its transient chaotic dynamics. In particular, we focus on how…

quant-ph2020

On an electrodynamic origin of quantum fluctuations

Álvaro G. López

In the present work we use the Liénard-Wiechert potential to show that very violent fluctuations are experienced by an electromagnetic charged extended particle when it is perturbe…

q-bio.OT2019★ 10 cited

Tumor stabilization induced by T-cell recruitment fluctuations

Irina Bashkirtseva, Lev Ryashko, Álvaro G. López +2

The influence of random fluctuations on the recruitment of effector cells towards a tumor is studied by means of a stochastic mathematical model. Aggressively growing tumors are co…

q-bio.PE2019★ 15 cited

The role of dose-density in combination cancer chemotherapy

Álvaro G. López, Kelly C. Iarosz, Antonio M. Batista +3

A multicompartment mathematical model is presented with the goal of studying the role of dose-dense protocols in the context of combination cancer chemotherapy. Dose-dense protocol…

q-bio.PE2018★ 25 cited

Nonlinear cancer chemotherapy: modelling the Norton-Simon hypothesis

Álvaro G. López, Kelly C. Iarosz, Antonio M. Batista +3

A fundamental model of tumor growth in the presence of cytotoxic chemotherapeutic agents is formulated. The model allows to study the role of the Norton-Simon hypothesis in the con…

nlin.CD2018★ 1 cited

Computing complex horseshoes by means of piecewise maps

Álvaro G. López, Álvar Daza, Jesús M. Seoane +1

A systematic procedure to numerically compute a horseshoe map is presented. This new method uses piecewise functions and expresses the required operations by means of elementary tr…

q-bio.PE2017

The dose-dense principle in chemotherapy

Alvaro G. Lopez, Kelly C. Iarosz, Antonio M. Batista +3

Chemotherapy is a class of cancer treatment that uses drugs to kill cancer cells. A typical chemotherapeutic protocol consists of several drugs delivered in cycles of three weeks.…

q-bio.TO2016★ 2 cited

On the fractional cell kill law governing the lysis of solid tumors

Álvaro G. López, Jesús M. Seoane, Miguel A. F. Sanjuán

We present in silico simulations and mathematical analyses supporting several hypotheses that explain the saturation expressed in the fractional cell kill law that governs the lysi…