91 citations · 387 across the 18 of their papers we have counts for
18 papers
Regional heterogeneity in left atrial stiffness impacts passive deformation in a cohort of patient-specific models
Tiffany MG Baptiste, Cristobal Rodero, Charles P Sillett +13
The deformation of the left atrium (LA), or its biomechanical function, is closely linked to the health of this cardiac chamber. In atrial fibrillation (AF), atrial biomechanics ar…
Computational Modeling of Selective Capture Mechanisms in Conduction System Pacing
Mohammadreza Kariman, Matthias A. F. Gsell, Edward J. Vigmond +3
CSP is gaining clinical significance owing to its ability to restore a physiological activation sequence in the ventricles. While His bundle pacing (HBP) producing the most physiol…
An efficient end-to-end computational framework for the generation of ECG calibrated volumetric models of human atrial electrophysiology
Elena Zappon, Luca Azzolin, Matthias A. F. Gsell +12
Computational models of atrial electrophysiology (EP) are increasingly utilized for applications such as the development of advanced mapping systems, personalized clinical therapy…
pyCEPS: A cross-platform Electroanatomic Mapping Data to Computational Model Conversion Platform for the Calibration of Digital Twin Models of Cardiac Electrophysiology
Robert Arnold, Anton J. Prassl, Aurel Neic +7
Background and Objective: Data from electro-anatomical mapping (EAM) systems are playing an increasingly important role in computational modeling studies for the patient-specific c…
Physics-informed Neural Network Estimation of Material Properties in Soft Tissue Nonlinear Biomechanical Models
Federica Caforio, Francesco Regazzoni, Stefano Pagani +5
The development of biophysical models for clinical applications is rapidly advancing in the research community, thanks to their predictive nature and their ability to assist the in…
A coupling strategy for a 3D-1D model of the cardiovascular system to study the effects of pulse wave propagation on cardiac function
Federica Caforio, Christoph M. Augustin, Jordi Alastruey +2
The impact of increased stiffness and pulsatile load on the circulation and their influence on heart performance have been documented not only for cardiovascular events but also fo…
An accurate, robust, and efficient finite element framework for anisotropic, nearly and fully incompressible elasticity
Elias Karabelas, Matthias A. F. Gsell, Gundolf Haase +2
Fiber-reinforced soft biological tissues are typically modeled as hyperelastic, anisotropic, and nearly incompressible materials. To enforce incompressibility a multiplicative spli…
Efficient identification of myocardial material parameters and the stress-free reference configuration for patient-specific human heart models
Laura Marx, Justyna A. Niestrawska, Matthias A. F. Gsell +3
Image-based computational models of the heart represent a powerful tool to shed new light on the mechanisms underlying physiological and pathological conditions in cardiac function…
A computationally efficient physiologically comprehensive 3D-0D closed-loop model of the heart and circulation
Christoph M. Augustin, Matthias A. F. Gsell, Elias Karabelas +5
Computer models of cardiac electro-mechanics (EM) show promise as an effective means for quantitative analysis of clinical data and, potentially, for predicting therapeutic respons…
Computational Modeling of Cardiac Growth and Remodeling in Pressure Overloaded Hearts -- Linking Microstructure to Organ Phenotype
Justyna A. Niestrawska, Christoph M. Augustin, Gernot Plank
Cardiac growth and remodeling (G&R) refers to structural changes in myocardial tissue in response to chronic alterations in loading conditions. One such condition is pressure overl…
Simulation of Cardiac Flow: Analysis of Geometry Simplification
Fanwei Kong, Christoph Augustin, Kevin Sack +1
Cardiovascular diseases (CVDs) are the leading causes of mortality worldwide. The contraction and relaxation of left ventricle (LV) is the main driving force of blood circulation.…
Versatile stabilized finite element formulations for nearly and fully incompressible solid mechanics
Elias Karabelas, Gundolf Haase, Gernot Plank +1
Computational formulations for large strain, polyconvex, nearly incompressible elasticity have been extensively studied, but research on enhancing solution schemes that offer bette…
FEniCS Mechanics: A Package for Continuum Mechanics Simulations
Miguel A. Rodriguez, Christoph M. Augustin, Shawn C. Shadden
FEniCS Mechanics is a Python package to facilitate computational mechanics simulations. The Python library dolfin, from the FEniCS Project, is used to formulate and numerically sol…
Phosphorylation by the stress-activated MAPK Slt2 down-regulates the yeast TOR complex 2
Kristin L. Leskoske, Françoise M. Roelants, Anita Emmerstorfer-Augustin +4
Saccharomyces cerevisiae target of rapamycin (TOR) complex 2 (TORC2) is an essential regulator of plasma membrane lipid and protein homeostasis. How TORC2 activity is modulated in…
Tracking yeast pheromone receptor Ste2 endocytosis using fluorogen-activating protein tagging
Anita Emmerstorfer-Augustin, Christoph M. Augustin, Shadi Shams +1
To observe internalization of the yeast pheromone receptor Ste2 by fluorescence microscopy in live cells in real time, we visualized only those molecules present at the cell surfac…
Towards a Computational Framework for Modeling the Impact of Aortic Coarctations upon Left Ventricular Load
Elias Karabelas, Matthias A. F. Gsell, Christoph M. Augustin +6
Computational fluid dynamics (CFD) models of blood flow in the left ventricle (LV) and aorta are important tools for analyzing the mechanistic links between myocardial deformation…
Assessment of wall stresses and mechanical heart power in the left ventricle: Finite element modeling versus Laplace analysis
Matthias A. F. Gsell, Christoph M. Augustin, Anton J. Prassl +6
Introduction: Stenotic aortic valve disease (AS) causes pressure overload of the left ventricle (LV) that may trigger adverse remodeling and precipitate progression towards heart f…
Classical and all-floating FETI methods for the simulation of arterial tissues
Christoph M. Augustin, Gerhard A. Holzapfel, Olaf Steinbach
High-resolution and anatomically realistic computer models of biological soft tissues play a significant role in the understanding of the function of cardiovascular components in h…