From the 1 of 5 linked papers with an AI index.
5 papers
A quantitative model for the emergent population dynamics of the melanoma MITF rheostat
Keith L. Chambers, Richard M. White, Colin R. Goding +1
The paper presents a multiscale PDE model linking subcellular MITF dynamics to melanoma population behavior, revealing three distinct stable phenotypic outcomes and showing that si…
A multiscale discrete-to-continuum framework for structured population models
Eleonora Agostinelli, Keith L. Chambers, Helen M. Byrne +1
Mathematical models of biological populations commonly use discrete structure classes to capture trait variation among individuals (e.g. age, size, phenotype, intracellular state).…
A spatially resolved and lipid-structured model for macrophage populations in early human atherosclerotic lesions
Keith L. Chambers, Mary R. Myerscough, Michael G. Watson +1
Atherosclerosis is a chronic inflammatory disease of the artery wall. The early stages of atherosclerosis are driven by interactions between lipids and monocyte-derived-macrophages…
An Asymptotic Analysis of Bivalent Monoclonal Antibody-Antigen Binding
Luke A Heirene, Helen M Byrne, James W T Yates +1
Ligand-receptor interactions are fundamental to many biological processes. For example in antibody-based immunotherapies, the dynamics of an antibody binding with its target antige…
Blood lipoproteins shape the phenotype and lipid content of early atherosclerotic lesion macrophages: a dual-structured mathematical model
Keith L Chambers, Mary R Myerscough, Michael G Watson +1
Macrophages in atherosclerotic lesions exhibit a spectrum of behaviours or phenotypes. The phenotypic distribution of monocyte-derived macrophages (MDMs), its correlation with MDM…