54 citations · 96 across the 8 of their papers we have counts for
8 papers · 1 filter
A novel inverse algorithm to solve IPO-IMPT of proton FLASH therapy with sparse filters
Nathan Harrison, Minglei Kang, Ruirui Liu +9
Purpose:The recently proposed IPO-IMPT framework allows simultaneous optimization of dose, dose rate, and LET for FLASH treatment planning. Finding solutions to IPO-IMPT is difficu…
Validation of the Quantum Physics Processes Underlying the Integrated Optimization of Proton FLASH Radiotherapy
Nathan Harrison, Serdar Charyyev, Cristina Oancea +6
FLASH is a new treatment modality that requires optimization of dose, dose rate, and LET. Here we validate these three quantities under FLASH conditions, which includes the quantum…
Deep learning-based Fast Volumetric Image Generation for Image-guided Proton FLASH Radiotherapy
Chih-Wei Chang, Yang Lei, Tonghe Wang +7
Proton FLASH therapy leverages ultra-high dose-rate radiation to enhance the sparing of organs at risk without compromising tumor control probability. To prepare for the delivery o…
Feasibility Study of Hybrid Inverse Planning with Transmission Beams and Single-energy Spread-out Bragg Peaks for Proton Flash Radiotherapy
Chaoqiong Ma, Xiaofeng Yang, Chih-Wei Chang +6
Ultra-high dose rate (FLASH) proton planning with only transmission beams (TBs) has limitations in normal tissue sparing. The single-energy spread-out Bragg peaks (SESOBPs) of FLAS…
Measurement of the time structure of FLASH beams using prompt gamma rays and secondary neutrons as surrogates
Serdar Charyyev, Ruirui Liu, Xiaofeng Yang +5
We aim to investigate the feasibility of online monitoring of irradiation time (IRT) and scan time for FLASH radiotherapy using a pixelated semiconductor detector. Measurements of…
Characterization of 250 MeV protons from Varian ProBeam pencil beam scanning system for FLASH radiation therapy
Serdar Charyyev, Chih-Wei Chang, Mingyao Zhu +3
Recently, shoot-through proton FLASH has been proposed where the highest energy is extracted from the cyclotron to maximize the dose rate (DR). Even though our proton pencil beam s…
An Integrated Biological Optimization framework for proton SBRT FLASH treatment planning allows dose, dose rate, and LET optimization using patient-specific ridge filters
Ruirui Liu, Serdar Charyyev, Niklas Wahl +10
Purpose: Patient-specific ridge filters can modulate proton energy to obtain a conformal dose. We describe a new framework for optimization of filter design and spot maps to meet t…
Learning-Based Stopping Power Mapping on Dual Energy CT for Proton Radiation Therapy
Tonghe Wang, Yang Lei, Joseph Harms +8
Purpose: Dual-energy CT (DECT) has been used to derive relative stopping power (RSP) map by obtaining the energy dependence of photon interactions. The DECT-derived RSP maps could…