3 papers
q-bio.BM2022
Methods for Cryo-EM Single Particle Reconstruction of Macromolecules having Continuous Heterogeneity
Bogdan Toader, Fred J. Sigworth, Roy R. Lederman
Macromolecules change their shape (conformation) in the process of carrying out their functions. The imaging by cryo-electron microscopy of rapidly-frozen, individual copies of mac…
physics.comp-ph2020
Computational Methods for Single-Particle Cryo-EM
Amit Singer, Fred J. Sigworth
Single-particle electron cryomicroscopy (cryo-EM) is an increasingly popular technique for elucidating the three-dimensional structure of proteins and other biologically significan…
eess.IV2018
Heterogeneous multireference alignment for images with application to 2-D classification in single particle reconstruction
Chao Ma, Tamir Bendory, Nicolas Boumal +2
Motivated by the task of 2-D classification in single particle reconstruction by cryo-electron microscopy (cryo-EM), we consider the problem of heterogeneous multireference alignme…