154 citations · 430 across the 16 of their papers we have counts for
17 papers
Mid-infrared Chemical Imaging of Intracellular Tau Fibrils using Fluorescence-guided Computational Photothermal Microscopy
Jian Zhao, Lulu Jiang, Alex Matlock +6
Amyloid proteins are associated with a broad spectrum of neurodegenerative diseases. However, it remains a grand challenge to extract molecular structure information from intracell…
Mid-Infrared Photothermal-Fluorescence in Situ Hybridization for Functional Analysis and Genetic Identification of Single Cells
Yeran Bai, Zhongyue Guo, Fátima C. Pereira +2
Simultaneous identification and metabolic analysis of microbes with single-cell resolution and high throughput is necessary to answer the question of "who eats what, when, and wher…
Multi-window SRS imaging using a rapid widely tunable fiber laser
Hongli Ni, Peng Lin, Yifan Zhu +4
Spectroscopic stimulated Raman scattering (SRS) imaging has become a useful tool finding a broad range of applications. Yet, wider adoption is hindered by the bulky and environment…
Bond-selective interferometric scattering microscopy
Celalettin Yurdakul, Haonan Zong, Yeran Bai +2
Interferometric scattering microscopy has been a very promising technology for highly sensitive label-free imaging of a broad spectrum of biological nanoparticles from proteins to…
Background-Suppressed High-Throughput Mid-Infrared Photothermal Microscopy via Pupil Engineering
Haonan Zong, Celalettin Yurdakul, Yeran Bai +3
Mid-infrared photothermal (MIP) microscopy has been a promising label-free chemical imaging technique for functional characterization of specimens owing to its enhanced spatial res…
Fluorescence-Enhanced Mid-Infrared Photothermal Microscopy
Yi Zhang, Haonan Zong, Cheng Zong +4
Mid-infrared photothermal microscopy is a new chemical imaging technology in which a visible beam senses the photothermal effect induced by a pulsed infrared laser. This technology…
Non-genetic acoustic stimulation of single neurons by a tapered fiber optoacoustic emitter
Linli Shi, Ying Jiang, Fernando R. Fernandez +6
As an emerging technology, transcranial focused ultrasound has been demonstrated to successfully evoke motor responses in mice, rabbits, and sensory/motor responses in humans. Yet,…
Vibrational Spectroscopic Detection of Single Virus by a Confocal Interferometric Mid-Infrared Photothermal Microscope
Yi Zhang, Alexander J. Devaux, John H. Connor +1
We report a confocal interferometric mid-infrared photothermal (MIP) microscope and its application to label-free detection of biological nanoparticles down to single virus level.…
Rapid Determination of Antimicrobial Susceptibility by Stimulated Raman Scattering Imaging of D2O Metabolic Incorporation in a Single Bacterium
Meng Zhang, Nader S. Abutaleb, Junjie Li +6
Rapid antimicrobial susceptibility testing (AST) is urgently needed for treating infections with correct antibiotics and slowing down the emergence of antibiotic-resistant bacteria…
Fingerprint Spectroscopic SRS Imaging of Single Living Cells and Whole Brain by Ultrafast Tuning and Spatial-Spectral Learning
Haonan Lin, Hyeon Jeong Lee, Nathan Tague +6
Label-free vibrational imaging by stimulated Raman scattering (SRS) provides unprecedented insight into real-time chemical distributions in living systems. Specifically, SRS in the…
Multiplex stimulated Raman scattering imaging cytometry reveals cancer metabolic signatures in a spatially, temporally, and spectrally resolved manner
Kai-Chih Huang, Junjie Li, Chi Zhang +2
In situ measurement of cellular metabolites is still a challenge in biology. Conventional methods, such as mass spectrometry or fluorescence microscopy, would either destruct the s…
A Fiber Optoacoustic Emitter with Maximized Conversion Efficiency and Controlled Ultrasound Frequency for Biomedical Applications
Linli Shi, Ying Jiang, Yi Zhang +4
Focused ultrasound has attracted great attention in minimally invasive therapy, gene delivery, brain stimulation, etc. Frequency below 1 MHz has been identified preferable for high…
Ultra-Efficient Conversion of Microwave into Ultrasound Wave through a Split Ring Resonator
Lu Lan, Yueming Li, Tiffany Yang-Tran +2
Thermo-elastic conversion of electromagnetic wave into ultrasound wave has enabled diverse biomedical applications such as photoacoustic imaging. Microwave, which has ~10 cm long w…
Plasmon-enhanced Stimulated Raman Scattering Microscopy with Single-molecule Detection Sensitivity
Cheng Zong, Ranjith Premasiri, Haonan Lin +6
Stimulated Raman scattering (SRS) microscopy allows for high-speed label-free chemical imaging of biomedical systems. The imaging sensitivity of SRS microscopy is limited to ~10 mM…
Bond-Selective Transient Phase Microscopy
Delong Zhang, Lu Lan, Yeran Bai +4
Phase-contrast microscopy converts the optical phase introduced by transparent, unlabeled specimens into modulation in the intensity image. Modern phase imaging techniques are capa…
Ultrafast Chemical Imaging by Widefield Photothermal Sensing of Infrared Absorption
Yeran Bai, Delong Zhang, Lu Lan +4
Infrared (IR) imaging has become a viable tool for visualizing various chemical bonds in a specimen. The performance, however, is limited in terms of spatial resolution and imaging…
Optimal coherent control of CARS: signal enhancement and background elimination
Fang Gao, Feng Shuang, JunHui Shi +3
The ability to enhance resonant signals and eliminate the non-resonant background is analyzed for Coherent Anti-Stokes Raman Scattering (CARS). The analysis is done at a specific f…