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Cryo-EM as a Stochastic Inverse Problem
Diego Sanchez Espinosa, Erik H Thiede, Yunan Yang
Cryo-electron microscopy (Cryo-EM) enables high-resolution imaging of biomolecules, but structural heterogeneity remains a major challenge in 3D reconstruction. Traditional methods…
physics.data-an2025★ 1 cited
Error Breakdown and Sensitivity Analysis of Dynamical Quantities in Markov State Models
Yehor Tuchkov, Luke Evans, Sonya M. Hanson +1
Markov state models (MSMs) are widely employed to analyze the kinetics of complex systems. But despite their effectiveness in many applications, MSMs are prone to systematic or sta…