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q-bio.TO2022
An optimization based 3D-1D coupling strategy for tissue perfusion and chemical transport during tumor-induced angiogenesis
Stefano Berrone, Chiara Giverso, Denise Grappein +2
A new mathematical model and numerical approach are proposed for the simulation of fluid and chemical exchanges between a growing capillary network and the surrounding tissue, in t…
math.NA2022
A PDE-constrained optimization method for 3D-1D coupled problems with discontinuous solutions
Stefano Berrone, Denise Grappein, Stefano Scialò
A numerical method for coupled 3D-1D problems with discontinuous solutions at the interfaces is derived and discussed. This extends a previous work on the subject where only contin…