162 citations · 546 across the 19 of their papers we have counts for
10 papers · 1 filter
Dataset creation for supervised deep learning-based analysis of microscopic images -- review of important considerations and recommendations
Christof A. Bertram, Viktoria Weiss, Jonas Ammeling +6
Supervised deep learning (DL) receives great interest for automated analysis of microscopic images with an increasing body of literature supporting its potential. The development a…
A bag of tricks for real-time Mitotic Figure detection
Christian Marzahl, Brian Napora
Mitotic figure (MF) detection in histopathology images is challenging due to large variations in slide scanners, staining protocols, tissue types, and the presence of artifacts. Th…
On the Value of PHH3 for Mitotic Figure Detection on H&E-stained Images
Jonathan Ganz, Christian Marzahl, Jonas Ammeling +20
The count of mitotic figures (MFs) observed in hematoxylin and eosin (H&E)-stained slides is an important prognostic marker as it is a measure for tumor cell proliferation. However…
Superpixel Pre-Segmentation of HER2 Slides for Efficient Annotation
Mathias Öttl, Jana Mönius, Christian Marzahl +8
Supervised deep learning has shown state-of-the-art performance for medical image segmentation across different applications, including histopathology and cancer research; however,…
How Many Annotators Do We Need? -- A Study on the Influence of Inter-Observer Variability on the Reliability of Automatic Mitotic Figure Assessment
Frauke Wilm, Christof A. Bertram, Christian Marzahl +23
Density of mitotic figures in histologic sections is a prognostically relevant characteristic for many tumours. Due to high inter-pathologist variability, deep learning-based algor…
Dataset on Bi- and Multi-Nucleated Tumor Cells in Canine Cutaneous Mast Cell Tumors
Christof A. Bertram, Taryn A. Donovan, Marco Tecilla +8
Tumor cells with two nuclei (binucleated cells, BiNC) or more nuclei (multinucleated cells, MuNC) indicate an increased amount of cellular genetic material which is thought to faci…
A completely annotated whole slide image dataset of canine breast cancer to aid human breast cancer research
Marc Aubreville, Christof A. Bertram, Taryn A. Donovan +3
Canine mammary carcinoma (CMC) has been used as a model to investigate the pathogenesis of human breast cancer and the same grading scheme is commonly used to assess tumor malignan…
Are pathologist-defined labels reproducible? Comparison of the TUPAC16 mitotic figure dataset with an alternative set of labels
Christof A. Bertram, Mitko Veta, Christian Marzahl +4
Pathologist-defined labels are the gold standard for histopathological data sets, regardless of well-known limitations in consistency for some tasks. To date, some datasets on mito…
Learning New Tricks from Old Dogs -- Inter-Species, Inter-Tissue Domain Adaptation for Mitotic Figure Assessment
Marc Aubreville, Christof A. Bertram, Samir Jabari +3
For histopathological tumor assessment, the count of mitotic figures per area is an important part of prognostication. Algorithmic approaches - such as for mitotic figure identific…
Deep learning algorithms out-perform veterinary pathologists in detecting the mitotically most active tumor region
Marc Aubreville, Christof A. Bertram, Christian Marzahl +9
Manual count of mitotic figures, which is determined in the tumor region with the highest mitotic activity, is a key parameter of most tumor grading schemes. It can be, however, st…