4 papers · 1 filter
Generalized promotion time cure model: A new modeling framework to identify cell-type-specific genes and improve survival prognosis
Zhi Zhao, Fatih Kızılaslan, Shixiong Wang +1
Single-cell technologies provide an unprecedented opportunity for dissecting the interplay between the cancer cells and the associated tumor microenvironment, and the produced high…
Bayesian Cox model with graph-structured variable selection priors for multi-omics biomarker identification
Tobias Østmo Hermansen, Manuela Zucknick, Zhi Zhao
An important goal in cancer research is the survival prognosis of a patient based on a minimal panel of genomic and molecular markers such as genes or proteins. Purely data-driven…
An ADMM approach for multi-response regression with overlapping groups and interaction effects
Theophilus Quachie Asenso, Manuela Zucknick
In this paper, we consider the regularized multi-response regression problem where there exists some structural relation within the responses and also between the covariates and a…
Structured penalized regression for drug sensitivity prediction
Zhi Zhao, Manuela Zucknick
Large-scale {\it in vitro} drug sensitivity screens are an important tool in personalized oncology to predict the effectiveness of potential cancer drugs. The prediction of the sen…