68 citations · 74 across the 7 of their papers we have counts for
3 papers · 1 filter
CauchyCP: a powerful test under non-proportional hazards using Cauchy combination of change-point Cox regressions
Hong Zhang, Qing Li, Devan V. Mehrotra +1
Non-proportional hazards data are routinely encountered in randomized clinical trials. In such cases, classic Cox proportional hazards model can suffer from severe power loss, with…
Principal Stratum Strategy: Potential Role in Drug Development
Björn Bornkamp, Kaspar Rufibach, Jianchang Lin +6
A randomized trial allows estimation of the causal effect of an intervention compared to a control in the overall population and in subpopulations defined by baseline characteristi…
Survival Analysis Using a 5-Step Stratified Testing and Amalgamation Routine in Randomized Clinical Trials
Devan V. Mehrotra, Rachel Marceau West
Randomized clinical trials are often designed to assess whether a test treatment prolongs survival relative to a control treatment. Increased patient heterogeneity, while desirable…