101 citations · 359 across the 16 of their papers we have counts for
5 papers · 1 filter
Prediction of gene expression time series and structural analysis of gene regulatory networks using recurrent neural networks
Michele Monti, Jonathan Fiorentino, Edoardo Milanetti +2
Methods for time series prediction and classification of gene regulatory networks (GRNs) from gene expression data have been treated separately so far. The recent emergence of atte…
A computational approach to investigate TDP-43 C-terminal fragments aggregation in Amyotrophic Lateral Sclerosis
Greta Grassmann, Mattia Miotto, Lorenzo Di Rienzo +7
Many of the molecular mechanisms underlying the pathological aggregation of proteins observed in neurodegenerative diseases are still not fully understood. Among the diseases assoc…
Investigating the side-chain structural organization behind the stability of protein folding and binding
Fausta Desantis, Mattia Miotto, Lorenzo Di Rienzo +2
What are the molecular mechanisms that dictate protein-protein binding stability and whether those are related to the ones behind protein fold stability are still largely open ques…
New algorithm to determine a minimal representation of the molecular surface
Greta Grassmann, Mattia Miotto, Lorenzo Di Rienzo +3
Most proteins perform their biological function by interacting with one or more molecular partners. In this respect, characterizing the features of the molecular surface, especiall…
Shape Complementarity Optimization of Antibody-Antigen Interfaces: the Application to SARS-CoV-2 Spike Protein
Alfredo De Lauro, Lorenzo Di Rienzo, Mattia Miotto +3
Many factors influence biomolecules binding, and its assessment constitutes an elusive challenge in computational structural biology. In this respect, the evaluation of shape compl…