6 papers
Aging-induced fragility of the immune system
Eric W. Jones, Jiming Sheng, Jean M. Carlson +1
The adaptive and innate branches of the vertebrate immune system work in close collaboration to protect organisms from harmful pathogens. As an organism ages its immune system unde…
Navigation and control of outcomes in a generalized Lotka-Volterra model of the microbiome
Eric W. Jones, Parker Shankin-Clarke, Jean M. Carlson
The generalized Lotka-Volterra (gLV) equations model the microbiome as a collection of interacting ecological species. Here we use a particular experimentally-derived gLV model of…
Control of ecological outcomes through deliberate parameter changes in a model of the gut microbiome
Zipeng Wang, Eric W. Jones, Joshua M. Mueller +1
The generalized Lotka-Volterra (gLV) equations are a mathematical proxy for ecological dynamics. We focus on a gLV model of the gut microbiome, in which the evolution of the gut mi…
Characterization of fracture in topology-optimized bio-inspired networks
Chantal Nguyen, Darin Peetz, Ahmed E. Elbanna +1
Designing strong and robust bio-inspired structures requires an understanding of how function arises from the architecture and geometry of materials found in nature. We draw from t…
Network models for characterization of trabecular bone
Avik Mondal, Chantal Nguyen, Xiao Ma +2
Trabecular bone is a lightweight, compliant material organized as a web of struts and rods (trabeculae) that erode with age and the onset of bone diseases like osteoporosis, leadin…
Steady State Reduction of generalized Lotka-Volterra systems in the microbiome
Eric W. Jones, Jean M. Carlson
The generalized Lotka-Volterra (gLV) equations, a classic model from theoretical ecology, describe the population dynamics of a set of interacting species. As the number of species…