Infectious diseases, imposing density-dependent mortality on MHC/HLA variation, can account for balancing selection and MHC/HLA polymorphism

D. P. L. Green

The human MHC transplantation loci (HLA-A, -B, -C, -DPB1, -DQB1, -DRB1) are the most polymorphic in the human genome. It is generally accepted this polymorphism reflects a role in…