45 citations · 87 across the 9 of their papers we have counts for
9 papers
Thermodynamic bounds on ultrasensitivity in covalent switching
Jeremy A. Owen, Pranay Talla, John W. Biddle +1
Switch-like motifs are among the basic building blocks of biochemical networks. A common motif that can serve as an ultrasensitive switch consists of two enzymes acting antagonisti…
Reformulating non-equilibrium steady-states and generalised Hopfield discrimination
Ugur Cetiner, Jeremy Gunawardena
Despite substantial progress in non-equilibrium physics, steady-state (s.s.) probabilities remain intractable to analysis. For a Markov process, s.s. probabilities can be expressed…
Reversal symmetries for cyclic paths away from thermodynamic equilibrium
John W. Biddle, Jeremy Gunawardena
If a system is at thermodynamic equilibrium, an observer cannot tell whether a film of it is being played forward or in reverse: any transition will occur with the same frequency i…
An energy-speed-accuracy relation in complex networks for biological discrimination
Felix Wong, Ariel Amir, Jeremy Gunawardena
Discriminating between correct and incorrect substrates is a core process in biology but how is energy apportioned between the conflicting demands of accuracy (), speed () an…
Complex-linear invariants of biochemical networks
R. L. Karp, M. Pérez Millán, T. Dasgupta +2
The nonlinearities found in molecular networks usually prevent mathematical analysis of network behaviour, which has largely been studied by numerical simulation. This can lead to…
A linear elimination framework
Jeremy Gunawardena
Key insights in molecular biology, such as enzyme kinetics, protein allostery and gene regulation emerged from quantitative analysis based on time-scale separation, allowing intern…