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stat.AP2026
Estimands and the Choice of Non-Inferiority Margin under ICH E9(R1)
Tobias Mütze, Helle Lynggaard, Sunita Rehal +3
Since the release of the ICH E9(R1) addendum on estimands, its application in non-inferiority trials has received far less attention than in superiority settings. A key conclusion…
stat.AP2023
Estimating hypothetical estimands with causal inference and missing data estimators in a diabetes trial
Camila Olarte Parra, Rhian M. Daniel, David Wright +1
The recently published ICH E9 addendum on estimands in clinical trials provides a framework for precisely defining the treatment effect that is to be estimated, but says little abo…