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stat.ME2020
It's All Relative: New Regression Paradigm for Microbiome Compositional Data
Gen Li, Yan Li, Kun Chen
Microbiome data are complex in nature, involving high dimensionality, compositionally, zero inflation, and taxonomic hierarchy. Compositional data reside in a simplex that does not…
stat.ME2020
The More Data, the Better? Demystifying Deletion-Based Methods in Linear Regression with Missing Data
Tianchen Xu, Kun Chen, Gen Li
We compare two deletion-based methods for dealing with the problem of missing observations in linear regression analysis. One is the complete-case analysis (CC, or listwise deletio…
stat.ME2020
Multivariate Log-Contrast Regression with Sub-Compositional Predictors: Testing the Association Between Preterm Infants' Gut Microbiome and Neurobehavioral Outcomes
Xiaokang Liu, Xiaomei Cong, Gen Li +2
The so-called gut-brain axis has stimulated extensive research on microbiomes. One focus is to assess the association between certain clinical outcomes and the relative abundances…