How old are dense core vesicles residing in en passant boutons: Simulation of the mean age of dense core vesicles in axonal arbors accounting for resident and transiting vesicle populations

I. A. Kuznetsov, A. V. Kuznetsov

In neurons, neuropeptides are synthesized in the soma and are then transported along the axon in dense core vesicles (DCVs). DCVs are captured in varicosities located along the axo…