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math.NA2026
Adaptive Fast-Slow Operator Splitting for Multiscale Biochemical Stochastic Dynamics
Yuming Zeng, Wei Xie, Keqi Wang
Stochastic reaction networks governed by Chemical Langevin Equations (CLE) exhibit pronounced multiscale dynamics spanning fast molecular reactions, intermediate transport, and slo…
q-bio.CB2026
Intracellular Measurement-Informed Multiscale Modeling for Scalable iPSC Manufacturing
Fuqiang Cheng, Zahra Foroozan Jahromi, Keqi Wang +10
Scalable manufacturing of human induced pluripotent stem cells (iPSCs) is essential for industrial-scale production of cell therapies and regenerative medicines. However, the 3D ag…
q-bio.MN2026
A Modular Mechanistic In Silico Model for In Vitro Transcription Process Yield and Product Quality Prediction
Keqi Wang, Keilung Choy, Eli Reiser +10
In vitro transcription (IVT) plays a critical role in the manufacture of mRNA vaccines and therapeutics. Optimizing mRNA yield and ensuring product quality, such as capping efficie…