6 citations · 13 across the 13 of their papers we have counts for
4 papers · 1 filter
A Modular Mechanistic In Silico Model for In Vitro Transcription Process Yield and Product Quality Prediction
Keqi Wang, Keilung Choy, Eli Reiser +10
In vitro transcription (IVT) plays a critical role in the manufacture of mRNA vaccines and therapeutics. Optimizing mRNA yield and ensuring product quality, such as capping efficie…
Multi-Scale Hybrid Modeling to Predict Cell Culture Process with Metabolic Phase Transitions
Keqi Wang, Sarah W. Harcum, Wei Xie
To advance understanding of cellular metabolism and reduce batch-to-batch variability in cell culture processes, this study introduces a multi-scale hybrid modeling framework desig…
Stochastic Molecular Reaction Queueing Network Modeling for In Vitro Transcription Process
Keqi Wang, Wei Xie, Hua Zheng
To facilitate a rapid response to pandemic threats, this paper focuses on developing a mechanistic simulation model for in vitro transcription (IVT) process, a crucial step in mRNA…
Metabolic Regulatory Network Kinetic Modeling with Multiple Isotopic Tracers for iPSCs
Keqi Wang, Wei Xie, Sarah W. Harcum
The rapidly expanding market for regenerative medicines and cell therapies highlights the need to advance the understanding of cellular metabolisms and improve the prediction of cu…