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clinical trials 1design of experiments 1estimation 1factorial designs 1statistical interactions 1

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stat.ME2026

Factorial clinical trials in the presence and absence of plausible statistical interactions between treatment factors. A historical review of the methodological literature

Rebecca E. A. Walwyn, Pritaporn Kingkaew, Alan A. Montgomery +2

The paper reviews the methodological literature on factorial clinical trials, contrasting guidance for when statistical interactions between treatment factors are expected versus n…