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A Differentiable Brain Tumor Mass Effect Solver
Marco L. Wittrich, Michal Balcerak, Lucas Zimmer +6
A growing brain tumor mechanically deforms the surrounding healthy brain through mass effect. This compression and displacement of tissue affects both patient prognosis and treatme…
From Fiber Tracts to Tumor Spread: Biophysical Modeling of Butterfly Glioma Growth Using Diffusion Tensor Imaging
Jonas Weidner, Ivan Ezhov, Michal Balcerak +5
Butterfly tumors are a distinct class of gliomas that span the corpus callosum, producing a characteristic butterfly-shaped appearance on MRI. The distinctive growth pattern of the…
A Lightweight Optimization Framework for Estimating 3D Brain Tumor Infiltration
Jonas Weidner, Michal Balcerak, Ivan Ezhov +6
Glioblastoma, the most aggressive primary brain tumor, poses a severe clinical challenge due to its diffuse microscopic infiltration, which remains largely undetected on standard M…
A Learnable Prior Improves Inverse Tumor Growth Modeling
Jonas Weidner, Ivan Ezhov, Michal Balcerak +11
Biophysical modeling, particularly involving partial differential equations (PDEs), offers significant potential for tailoring disease treatment protocols to individual patients. H…
Individualizing Glioma Radiotherapy Planning by Optimization of Data and Physics-Informed Discrete Loss
Michal Balcerak, Jonas Weidner, Petr Karnakov +8
Brain tumor growth is unique to each glioma patient and extends beyond what is visible in imaging scans, infiltrating surrounding brain tissue. Understanding these hidden patient-s…
Learn-Morph-Infer: a new way of solving the inverse problem for brain tumor modeling
Ivan Ezhov, Kevin Scibilia, Katharina Franitza +12
Current treatment planning of patients diagnosed with a brain tumor, such as glioma, could significantly benefit by accessing the spatial distribution of tumor cell concentration.…