2 papers
stat.ME2022
Point estimation for adaptive trial designs II: practical considerations and guidance
David S. Robertson, Babak Choodari-Oskooei, Munya Dimairo +3
In adaptive clinical trials, the conventional end-of-trial point estimate of a treatment effect is prone to bias, that is, a systematic tendency to deviate from its true value. As…
stat.AP2020
Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs
Thomas Burnett, Pavel Mozgunov, Philip Pallmann +3
Adaptive designs for clinical trials permit alterations to a study in response to accumulating data in order to make trials more flexible, ethical and efficient. These benefits are…